MedWire
(7/15, Davenport) reported, "The association between prostate cancer risk and single nucleotide polymorphisms (SNPs) on chromosome 8q24 is particularly strong among individuals predisposed to early onset or clinically aggressive disease," according to a study in the International Journal of Cancer. The researchers studied "the associations between the chromosomal region and the risk of hereditary cancer" by "genotyp[ing] 542 affected and 473 unaffected men from 403 nonHispanic White men from familial and early-onset prostate cancer families for six of the seven markers." They found "that the SNPs rs6983561 and rs6983267 had the strongest association with prostate cancer, with the minor C allele and major G allele, respectively, preferentially transmitted to affected men, at odds ratios of 2.26 and 1.30." The researchers added "that the rs6983561 C allele was significantly associated with prostate cancer only among men diagnosed before 50 years of age,...while the rs6983267 was significantly associated with prostate cancer only in men with clinically aggressive disease."